CYROMAZINE X - X JMPR 2006 CYROMAZINE First draft prepared
نویسندگان
چکیده
Explanation ..................................................................................................... 227 Evaluation for acceptable daily intake ............................................................ 228 1. Biochemical aspects .......................................................................... 228 1.1 Absorption, distribution and excretion ...................................... 228 1.2 Biotransformation ...................................................................... 237 1.3 Dermal absorption ..................................................................... 243 2. Toxicological studies ......................................................................... 250 2.1 Acute toxicity ............................................................................ 250 (a) Lethal doses ........................................................................ 250 (b) Dermal and ocular irritation and dermal sensitization ....... 251 2.2 Short-term studies of toxicity .................................................... 252 2.3 Long-term studies of toxicity and carcinogenicity .................... 257 2.4 Genotoxicity .............................................................................. 262 2.5 Reproductive toxicity ................................................................. 266 (a) Multigeneration studies ...................................................... 266 (b) Developmental toxicity ...................................................... 268 2.6 Special studies: neurotoxicity .................................................... 276 3. Studies on metabolites ....................................................................... 277 3.1 Absorption, distribution, excretion and metabolism ................. 277 3.2 Toxicological studies ................................................................. 277 (a) Acute toxicity ..................................................................... 277 (b) Short-term studies of toxicity ............................................ 278 (c) Long-term studies of toxicity and carcinogenicity ............. 279 (d) Genotoxicity ....................................................................... 282 (e) Reproductive toxicity ......................................................... 283 (f) Special studies .................................................................... 283 4. Observations in humans .................................................................... 283 Comments ....................................................................................................... 283 Toxicological evaluation ................................................................................. 286 References ....................................................................................................... 288
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